Well, since then, I've purchased a new MacBook Pro complete with an Apple Remote and have started playing around with Griffin's Proxi. Proxi is a very polished, free, event manager for OS X and, after about 10 minutes, I had knocked up a 'blueprint' for controlling the Last.fm client using the Apple Remote.
You can download the first incarnation from here.
Comments and suggestions are welcome.
Nice job! Great use of Proxi.